This site is intended for healthcare professionals only

Adherence, smoking, arthritis

Written by: | Published:

Varenicline effective in mentally ill smokers

JAMA (2014) 311(2):145-154 doi: 10.1001/jama.2013.285113

People with serious mental illnesses who quit smoking are three times less likely to relapse following maintenance varenicline, than after placebo. This study is the first randomised, controlled trial assessing maintenance therapy to prevent smoking relapse in people with serious mental illnesses.

People with schizophrenia spectrum disorders (approximately 90 per cent of those enrolled) or bipolar disease who were continuously abstinent for at least two weeks after 12 weeks of open-label treatment with varenicline and cognitive behavioural therapy (CBT) entered the relapse-prevention phase. During this phase, patients received CBT and either varenicline (1 mg twice daily) or placebo from weeks 12 to 52. They then discontinued treatment and were followed until week 76. Sixty-one people completed the relapse-prevention phase.

Please login or register to read the rest of the article and to have access to downloads and comments.

What do you think? Leave a comment below or tweet your views to @IndyNurseMag

This material is protected by MA Healthcare Ltd copyright.
See Terms and Conditions.

Read a free issue from Practice Nursing

Register to read a free issue from our sister publication, Practice Nursing.

Including articles on asthma, diabetes and more. Read your copy.


Sign up to the newsletter


Independent Nurse is the professional resource for primary care and community nurses, providing clinical articles for practice nurses and prescribers.


Subscribe to our newsletter and stay up to date with the latest nursing news.

Stay Connected

Stay social with Independent Nurse by following us on Twitter, liking us on Facebook or connecting on LinkedIn.


Need access to some of our older articles? You can view our archive, or alternatively contact us.

Contact Us

MA Healthcare Ltd.
St Jude's Church, Dulwich Road
London, SE24 0PB

Tel: +44 (0)20 7738 5454
Registered in England and Wales No. 01878373

Meet the team


Find out how to contribute to Independent Nurse here.