Measuring blood levels of two biomarkers - asymmetric dimethylarginine (ADMA) and homocysteine - might detect women at high risk of developing pre-eclampsia.
The authors measured levels of ADMA, homocysteine, vitamins B6, B12, and folic acid every month from 20 weeks or less of gestation until delivery in 252 women. ADMA inhibits nitric oxide synthase. This enzyme generates nitric oxide, which protects the vascular system. Homocysteine protects against free radicals and endothelial damage.