This site is intended for healthcare professionals only

Contraceptive product update

Written by: | Published:

Subcutaneous depot medroxyprogesterone acetate

Sayana Press is a progestogen-only injectable contraceptive for subcutaneous (SC) use. It is bioequivalent to intramuscular (IM) depot med-roxy-progesterone acetate (150mg Depo-Provera).1 This type of contraception prevents ovulation. Both SC and IM methods may be associated with loss of bone mineral density, amenorrhoea, weight gain and a delayed return to fertility. Sayana Press contains 104mg medroxyprogesterone acetate in 0.65ml suspension and is licensed to be administered at intervals of 13 weeks +/− seven days. It comes as a single dose pre-filled injector. The injection is delivered into the upper anterior thigh or the anterior abdomen. It should be stored at room temperature.1

Advantages of SC administration include the potential for self-administration and a reduction in the likelihood of haematomas in patients with bleeding disorders or on anticoagulation therapy. Note that self-administration is outside product licence.1 Injection site reactions range from bruising to scarring. SC administration may be helpful in obese women where there may be concern about IM Depo-Provera reaching muscle.1

Please login or register to read the rest of the article and to have access to downloads and comments.

What do you think? Leave a comment below or tweet your views to @IndyNurseMag

This material is protected by MA Healthcare Ltd copyright.
See Terms and Conditions.

Read a free issue from Practice Nursing

Register to read a free issue from our sister publication, Practice Nursing.

Including articles on asthma, diabetes and more. Read your copy.


Sign up to the newsletter


Independent Nurse is the professional resource for primary care and community nurses, providing clinical articles for practice nurses and prescribers.


Subscribe to our newsletter and stay up to date with the latest nursing news.

Stay Connected

Stay social with Independent Nurse by following us on Twitter, liking us on Facebook or connecting on LinkedIn.


Need access to some of our older articles? You can view our archive, or alternatively contact us.

Contact Us

MA Healthcare Ltd.
St Jude's Church, Dulwich Road
London, SE24 0PB

Tel: +44 (0)20 7738 5454
Registered in England and Wales No. 01878373

Meet the team


Find out how to contribute to Independent Nurse here.