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Contraceptive product update

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Subcutaneous depot medroxyprogesterone acetate

Sayana Press is a progestogen-only injectable contraceptive for subcutaneous (SC) use. It is bioequivalent to intramuscular (IM) depot med-roxy-progesterone acetate (150mg Depo-Provera).1 This type of contraception prevents ovulation. Both SC and IM methods may be associated with loss of bone mineral density, amenorrhoea, weight gain and a delayed return to fertility. Sayana Press contains 104mg medroxyprogesterone acetate in 0.65ml suspension and is licensed to be administered at intervals of 13 weeks +/− seven days. It comes as a single dose pre-filled injector. The injection is delivered into the upper anterior thigh or the anterior abdomen. It should be stored at room temperature.1

Advantages of SC administration include the potential for self-administration and a reduction in the likelihood of haematomas in patients with bleeding disorders or on anticoagulation therapy. Note that self-administration is outside product licence.1 Injection site reactions range from bruising to scarring. SC administration may be helpful in obese women where there may be concern about IM Depo-Provera reaching muscle.1


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