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Diabetes arising from pancreatic exocrine problems

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Pancreatic damage can lead to diabetes Pancreatic damage can lead to diabetes, and even onto pancreatic cancer

The pancreas serves the dual function of being both an endocrine (hormone secreting) and exocrine (digestive enzyme producing) organ, and the interdependency of pancreatic endocrine and exocrine function is increasingly recognised. When pancreatic exocrine disease leads to diabetes mellitus the latter is termed pancreatogenic (or type 3c) diabetes mellitus, a distinct entity from type 1 or type 2 diabetes.1

Pancreatogenic diabetes is frequently misclassified (often as type 2 diabetes) which can lead to suboptimal management. It is therefore important for the primary care practitioner to be alert to the possibility of type 3c diabetes. Treatment of both the diabetes and the pancreatic exocrine insufficiency (PEI), which leads to malabsorption, are necessary. Diabetes from pancreatic damage can be problematic to control with wide swings from hyperglycaemia to hypoglycaemia – so called ‘brittle diabetes’ – due to the nature of the hormone deficiency.

What causes pancreatogenic diabetes?

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Brilliant discussion on diagnosis and management of type 3 D M .i am a physician cardiologist who has suffered due to g i symptoms for the past 20 yrs and type 2 with metabolic syndrom .recently i had for some reason symtoms akin to o h a failure and.have been started on a small dose of regludec ie 3 unitsof aspart and 7 units of degludec a total of 10 units once daily before breakfast in addition to o h a three times a day which i was already on and.i am feeling much better symptomatically and otherwise kind rgds dr t m s prasad panicker medical director s m memorial superspeciality centre north parur kerala india
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