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Human papilloma virus (HPV) and cervical cancer

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Nearly 1000 women die in the UK each year Nearly 1000 women die in the UK each year due to cervical cancer, which is almost always caused by HPV

The eradication of cervical cancer; a human papilloma virus (HPV) related malignancy of the cervical mucosa had become a recent topic of discussion in the media. This follows on from the research conducted into the outcomes of HPV vaccination programme.

This article will look at the research findings and the potential impact this will have on the National Health Service Cervical Screening programme.

The World Health Organisation calculates that cervical cancer was the fourth most common cancer is women worldwide with approximately 530,000 new cases in 2012. The estimated mortality was 270,000.1

In the UK, cervical cancer is the 14th most common cancer in women, with around 3200 new cases reported in 2016.
In that year there were estimated to be 870 deaths from cervical cancer.2

Cervical cancers are preceded by a long phase of preinvasive disease, which is characterised microscopically as a spectrum of cell changes: progressing from cellular atypia to various grades of dyskaryosis (identified at cytological examination stage); to cervical intraepithelial neoplasia (CIN) (identified at histological stage); before progression to invasive disease.


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