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Artificial Pancreas – Hybrid Closed Loop: an impending revolution

Navya Basavaraju, Annamarie Jones, and Probal K Moulik detail the latest breakthrough in diabetes management
The closed-loop insulin delivery system, also known as an artificial pancreas, has evolved from bulky, bedside machines to miniaturized, wearable devices

Type 1 diabetes is one of the long-term conditions which poses a challenge for self-management. There are approximately 400,000 people living with type 1 diabetes in the UK, including 29,000 children and the incidence is increasing.1

The goal of treatment in type 1 diabetes is to achieve a blood glucose within a healthy range by supplemental insulin. However, very high level of circulating insulin can cause very low blood glucose levels leading to hypoglycaemia.

Suboptimal control of type 1 diabetes results in increased risk of long-term complications including both microvascular complications such as retinopathy and blindness, neuropathy, nephropathy; and macrovascular complications such as ischaemic heart disease, stroke, and peripheral vascular disease.

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